Accordingly, either a quadruple regression model consisting of OHI score, GCF sclerostin, GCF MMP-9, and GCF PGE2 or the combined measurements of GCF sclerostin and GCF PGE2 were deemed more appropriate for predicting AP-related resorption in the periapical region. The gene discussed is MMP9; the disease is alkaline phosphatase measurement.