Under hypoxic conditions, overexpression of miR-675-5p can further enhance the level of HIF-1α, which, as the main transcription factor of VEGF, promotes the expression of VEGF and, in synergy with ICAM-1, promotes angiogenesis, showing advantages in improving cardiac function and reducing infarct size in a rat model of MI [328]. Here, VEGFA is linked to myocardial infarction.