IL-1 receptor-associated kinase 3 (IRAK-3/IRAK-M), an anti-inflammatory mediator secreted by fibroblasts and macrophages in the infarct zone, inhibits the inflammatory response following MI by reducing cellular responsiveness to pro-inflammatory signals, expressing decoy cytokines and chemokine receptors, and releasing soluble anti-inflammatory mediators [14]. The gene discussed is IRAK3; the disease is myocardial infarction.