TGFB1 and myocardial infarction: For example, in a rat MI model, following MSCs transplantation, the mRNA and protein expression of type I collagen, type III collagen, TIMP-1/2, and TGF-β1 in the tissue were significantly reduced, while left ventricular systolic pressure and left ventricular systolic and diastolic peak velocities were significantly increased [271, 272].