This study provided a comprehensive evaluation of systemic amyloidosis using whole-body 11C-PIB PET/CT imaging in 70 patients, divided into subtypes including transthyretin (ATTR) amyloidosis (n = 18), light-chain (AL) amyloidosis (n = 22), amyloid A (AA) amyloidosis (n = 3), and a control group without amyloidosis (NC, n = 27). This evidence concerns the gene TTR and primary systemic amyloidosis.