CD4 and uveitis: Grounded on our previous studies demonstrating the pathogenic roles of memory CD4+ T cells in chronic uveitis,29 as well as increased memory CD4+ T cells in the peripheral blood of uveitis patients20,42,43 and association of memory T-cell differentiation pathway with clinical disease from a large-scale bioinformatics analysis of uveitis patients data,44 the present study has further provided proof-of-concept evidence supporting a novel therapeutic strategy targeting the long-lived, pathogenic memory CD4+ T cells in chronic uveitis to achieve sustained disease remission.