PKM and cancer: For instance, the serine/arginine‐rich protein SRSF1 is upregulated in many cancers and proven to promote tumorigenesis.[17, 19] Similarly, the over‐expression of specific heterogeneous nuclear ribonucleoproteins (hnRNPs) results in the exclusion of exon 9 of pyruvate kinase muscle (PKM), leading to a switch of cellular metabolism in glioma.[20] These findings suggest that the altered RBP expressions function as a potential contributor to splicing disorders.