This PPV threshold is comparable with two representative benchmarks: first, the likelihood that cancer is detected in individuals with Li–Fraumeni syndrome (those who are at genetic risk of cancer due to a TP53 gene alteration) during recommended whole-body MRI (22, 23); and second, the PPV of Guy’s Rapid Diagnostic Clinic in England dedicated to the diagnostic workup for individuals with increased suspicion of cancer (24). This evidence concerns the gene TP53 and cancer.