Compelling evidence indicates that the Tau‐Fyn interaction might be crucial in the synaptic damage observed at early stages of neurodegeneration in AD.[3, 4, 5, 6] In this regard, high‐resolution information of this molecular recognition event could improve our understanding of the key mechanisms that regulate proteins missorting to the post‐synapse and provide a better framework for the design of selective inhibitors targeting synaptotoxicity in tauopathies. This evidence concerns the gene MAPT and Alzheimer disease.