<h4>Objectives</h4>To summarize the clinical, electroencephalogram (EEG), and imaging characteristics of patients with anti-leucine-rich glioma-inactivated 1 autoimmune encephalitis (LGI1-AE) and provide a reference for clinical diagnosis and treatment.<h4>Methods</h4>We retrospectively analyzed 88 patients diagnosed with LGI1-AE between January 2018 and April 2024 in the Department of Neurology, Huashan Hospital, Fudan University, and the First Hospital of Jilin University.<h4>Results</h4>This retrospective study analyzed 88 patients diagnosed with LGI1-AE. Here, LGI1 is linked to autoimmune encephalitis.