This study has revealedthat miR-129-3p plays critical role in ICC pathogenesis and can act as a potential target for its treatment [46].The role of MiR-129-2-3p as a cancer repressor was also revealed in EC (esophageal carcinoma) cell [47].Role of miR-130a in both Hepatitis C Virus and Hepatitis B Virus regulation has been revealed [48].MiR-130a regulates replication through targeting the PKLR gene (gene encoding pyruvate kinase in liver and red blood cell)[48]. This evidence concerns the gene PKLR and intrahepatic cholangiocarcinoma.