It was discovered that miR-138-5p impaired the replication and expression of HBV bydown-regulating TNFAIP3 (codes for tumor necrosis factor, alpha-induced protein 3 or A20) [49].Investigations have demonstrated the crucial role played by miR-138-5p in regulation of various cancers through mediation of biologicalprocesses, such as, prostate cancer (combines with FOXC1 [Forkhead box C1]) [50] breast carcinoma(binds to RHBDD1 [rhomboid domain containing 1]) [51], hepatocellular carcinoma (astumor-suppressing factor) [52]. This evidence concerns the gene TNFAIP3 and hepatocellular carcinoma.