CLU and Alzheimer disease: Genome-wide association studies (GWAS) indicate the third strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD) is a single nucleotide polymorphism (SNP) in a gene that encodes for clusterin (CLU), a multifunctional chaperone protein directly involved in a wide range of AD-associated biological processes, including Aβ and tau metabolism, lipid transport, immune modulation, oxidative stress, and apoptosis4.