COL11A1 and neoplasm: Additionally, significant changes were observed in the expression of chemokines and chemokine receptors in tumor tissues with COL11A1 mutations, suggesting that COL11A1 mutations might affect chemotaxis signaling in the tumor microenvironment, thereby influencing immune cell invasion. We also used various methods to verify the relationship between COL11A1 mutation and immune infiltration, further validating our observations.