Pelvic organ prolapse is also characterized by the presence of non-significant levels of tissue fibrosis markers such as fibroblast growth factor (FGF), transforming growth factor β (TGF-β), insulin-like growth factor (IGF), and the transmembrane glycoprotein CD44 whose role is to alter the balance between production and degradation of components of the extracellular matrix. Here, CD44 is linked to pelvic organ prolapse.