ART4 and migraine disorder: However, the glycocalyx is an important contributor to NO-induced vasodilation.43 Studies demonstrated that diminished glycocalyx components are associated with reduced or absent NO-induced vasodilation.28,33,55 Given that NO is known to induce human migraine attacks, increased glycoprotein and proteoglycan production may provide a link connecting elevated cortisol concentrations with the attack.36,37,40 Indeed, following the neuroendocrine challenge, the patient's status gradually deteriorated to the point, when i.v. medications were administered.