These markers include epidermal growth factor (EGF), interleukin 10 (IL-10), colony stimulating factor 3 (CSF3), interleukin 1 receptor antagonist (IL-1RN), colony stimulating factor 2 (CSF2), CCL22, interleukin 13 (IL-13), interleukin 15 (IL-15), and interleukin 6 (IL-6), all of which have significant roles in the development and progression of dental caries [17]. This evidence concerns the gene EGF and dental caries.