ATXN1 and experimental autoimmune encephalomyelitis: To examine the role of ATXN1 in EAE, we immunized 8-week-old WT, f-ATXN1146Q/2Q, and Atxn12Q/− female mice, with myelin oligodendrocyte glycoprotein (MOG) peptide 35 to 55 (MOG35–55) to induce experimental autoimmune encephalomyelitis (EAE).