To test the hypothesis of epigenetic regulation of DEGs associated with MM progression, we conducted scMultiome (single-cell, paired RNA/ATAC-Seq) on 18 CD138+ BM aspirate samples from 2 healthy donors, 3 MGUS, 4 SMM, 3 NDMM (including a sequential sample from SMM), 1 ERMM, and 5 LRMM patients, ranging from 5,361 to 11,293 cells per sample (patients’ demographics and cytogenetics in Table S10). Here, SDC1 is linked to Miyoshi myopathy.