MYC and cancer: Finally, we demonstrated that the expression (ssGSEA NES) of the gene set defining the high-risk subtype “PR”, positively correlates with Cancer Hallmarks linked to PC1>0 (e.g., OXPHOS, G2M Checkpoint, MYC Targets, etc.), and inversely correlates with those associated with PC1<0 (e.g., EMT, Inflammatory Response, etc.)(Figure S4M).