As expected, there was a strong correlation between three UAMS subgroups and specific cytogenetic abnormalities in our cohort: (i) the “MS” subgroup, characterized by FGFR3 overexpression, was associated with t(4;14); (ii) the “CD-1” and “CD-2” subgroups, marked by CCND1 overexpression, were linked to t(11;14); and (iii) the “MF” subgroup, defined by MAF overexpression, was associated with t(14;16) (p<0.001 for all comparisons, Fisher’s Exact test) (Figure 1D). The gene discussed is CCND1; the disease is myeloid sarcoma.