L‐Arginine demonstrates multifaceted metabolic regulatory capacities, including maintaining glucose homeostasis, enhancing insulin sensitivity via nitric oxide (NO)‐mediated improvement of vasodilatory responses and glucokinase activity, preserving pancreatic β‐cell integrity, mitigating diabetes‐induced oxidative stress, and attenuating insulin resistance (Hu et al. 2017). Here, INS is linked to diabetes mellitus.