Sciatic nerve proteomics showed a significant increase in LRP group myosin, TNN13, MYL7, MYL3, TNNC, MYBPC2, ACTN2, and KEGG enrichment analyses showed that these proteins were mainly enriched in pathways such as cardiac contraction, diabetic cardiomyopathy, and dilated heart disease. The gene discussed is MYL3; the disease is diabetic cardiomyopathy.