Sciatic nerve proteomics showed a significant increase in LRP group myosin, TNN13, MYL7, MYL3, TNNC, MYBPC2, ACTN2, and KEGG enrichment analyses showed that these proteins were mainly enriched in pathways such as cardiac contraction, diabetic cardiomyopathy, and dilated heart disease. Here, TNNC1 is linked to diabetic cardiomyopathy.