TNFSF10 and Hepatic fibrosis: These NPs, with a diameter of about 227 nm, displayed selective targeting and efficient delivery of TRAIL to activated HSCs, which are key players in liver fibrosis progression, leading to their apoptosis.11 The cell membrane coating on the NPs enabled them to avoid the RES by providing a stealthy surface that reduces recognition by immune cells and prolongs circulation time in the bloodstream.