The HSC-coated PLGA NPs of size 108 nm showed homologous targeting towards aHSCs and demonstrated efficient treatment by increased apoptosis of aHSCs via inhibition of NF-κB pathway, ultimately causing a reduction in collagen production, promising to be an effective treatment modality for liver fibrosis (Fig. 2). Here, NFKB1 is linked to Hepatic fibrosis.