Within the aHSCs, the dysregulated NF-κB signals lead to prolonged cell survival and apoptosis resistance.29 Recently, Cheng and his coworkers developed a biomimetic nanosystem that comprises HSC membranes coated onto polymeric poly lactic-co-glycolic acid (PLGA) NPs encapsulated with an NF-κB inhibitor BAY 11-7082.121 This inhibitor of NF-κB been known to hinder the development and progression of liver fibrosis by inducing apoptosis in aHSCs. The gene discussed is NFKB1; the disease is Hepatic fibrosis.