TNFSF10 and hepatocellular carcinoma: In the above formulation, Xia et al. encapsulated all-trans retinoic acid (ATRA) within the polymer core of their biomimetic NPs, which worked synergistically with NP-delivered TRAIL to induce quiescence of those activated HSCs (aHSCs) that are TRAIL-resistant.11 In this review, we will discuss current research on the use of biomimetic NP formulations particularly in the context of liver fibrosis and HCC treatment, as these diseases pose significant global health challenges due to their rising incidence in recent years.