The lead SNP rs9347170 in this region is near the CEP43 gene, and a recent proteomic based Mendelian Randomization study has identified the gene as a causal target for the risk of lung cancer.66 The 6q27 locus also contains other tumour suppressor genes such as DLL1 involved in NOTCH1 cell signaling pathway. This evidence concerns the gene NOTCH1 and lung carcinoma.