Of the 61 genes with evidence for an association between their expression and CRC risk, six had evidence for a shared signal with CRC risk (H4>0.8): FADS2, FHL3, HLA-DRB1, HLA-DRB5, RPL28, and TMEM258 (Table 1; full results in supplementary table 4). This evidence concerns the gene RPL28 and colorectal carcinoma.