For example, MR results suggested a protective effect of higher TMEM258 expression on female-specific CRC risk in CD4 naïve cells (OR= 0.89, confidence interval (CI)= 0.85 to 0.93) and TN cells at rest (OR= 0.89, CI= 0.85 to 0.93) but not on male-specific CRC risk. This evidence concerns the gene TMEM258 and colorectal carcinoma.