The role of p21 and its transcriptional downregulation by ZNF224 in conditions of impaired p53 transcriptional activity deserves further investigation to better characterize the role of ZNF224 in cancers with different p53/p21 assets, by studying its possible involvement in tumor progression in terms of growth and invasion potential [44, 45, 46]. This evidence concerns the gene CDKN1A and neoplasm.