Afterwards, ZNF224 showed unexpected properties of a transcriptional activator in different cellular contexts like breast cancer or chronic lymphocytic leukemia (CLL), where it causes cell proliferation and inhibits apoptosis through the transcriptional activation of miR‐633 and cyclin D genes, respectively [5, 6, 7]. The gene discussed is ZNF224; the disease is B-cell chronic lymphocytic leukemia.