The above‐described proproliferative and anti‐apoptotic function of ZNF224 in melanoma cell lines prompted us to investigate whether the increased p21 expression, observed in A375 cells, could be a suitable cause of ZNF224‐induced proliferation, which leads to the dramatic increase of melanoma cell growth, rather than to cell cycle arrest and induction of apoptotic events. Here, ZNF224 is linked to melanoma.