Given the relevant role of ZNF224 in the NF‐kB pro‐survival pathway activation in some tumors [7, 15], we could hypothesize that it induces the pro‐survival activity of wild‐type p53 in melanoma cells, stimulating its capability to drive NF‐kB signaling activation and pro‐inflammatory cytokine production [47]. The gene discussed is TP53; the disease is melanoma.