CSE might also modify elements related to ECM degradation or turnover, because caffeine decreased MMP‐2 and MMP‐9 activity in a rat model of liver fibrosis (Arauz et al., 2014), and cocoa procyanidins inhibited the expression and activation of MMP‐2 in human vascular SMCs (Lee et al., 2008). Here, MMP2 is linked to Hepatic fibrosis.