Proteomic analysis using SC samples showed that the FF film treatment with lotion decreased annexin A2, a dry skin marker, whereas it increased retroviral-like aspartic protease 1, which is related to skin water content, more than lotion alone.<h4>Conclusion</h4>The present findings suggest that lotion with the FF film initiates restoration of epidermal homeostasis, leading to early improvement of dry skin. This evidence concerns the gene ANXA2 and Dry skin.