Based on previous studies and analyses of genetic data, the authors presented a comprehensive analysis of the interactions between mRNAs and miRNAs in EEC tissues, constructed a Mrna-miRNA co‐expression network, and finally selected four miRNAs (miR-1277–3p, miR142–5p, miR-455–5p, and miR-30a-5p) and two mRNAs (SACS and GPR157) with prognostic potential in EEC. Here, SACS is linked to exstrophy-epispadias complex.