Notably, we observed strong DPEP1 staining on microvascular tips, marked by DLL-4 co-staining and spatial mRNA expression (Figure 5G, and Supplementary Figure S11A-Top panel, S11B) on vascular sprouts, in contrast to the weaker staining observed in mature vascular structures in glioblastoma (Supplementary Figure 10D). This evidence concerns the gene DLL4 and glioblastoma.