To further validate the clinical relevance of DPEP1, we analyzed the The Cancer Genome Atlas-Glioblastoma-Low Grade Glioma (TCGA-GBM-LGG) dataset, revealing significantly higher expression of DPEP1 in isocitrate dehydrogenase (IDH)-wild type tumors compared to lower-grade gliomas with IDH mutation. The gene discussed is IDH3A; the disease is central nervous system cancer.