Targeting DPEP1 with cilastatin significantly suppressed DPEP1 expression (Figure 6I) and reduced the angiogenic sprout area in both glioblastoma-derived vascular sprouts (Figure 6J-K) and mouse aortic ring assays without inducing toxicity (Figure 6L, Supplementary Figure S10I), highlighting its potential as a therapeutic target. The gene discussed is DPEP1; the disease is glioblastoma.