Significant upregulation was observed in terms including fructose 6-phosphate metabolic process, pyruvate metabolic process, glycolytic process, positive regulation of angiogenesis, and positive regulation of chemotaxis in DPEP1-expressing lesions (Figure 6D), confirming DPEP1-rich microenvironments as a hypermetabolic region in the glioblastoma microenvironment. This evidence concerns the gene DPEP1 and glioblastoma.