DPEP1 and neoplasm: Other studies focused on dipeptidase 1, demonstrated that DPEP1 mediates neutrophil and monocyte influx in the lungs and liver by serving as a physical adhesion receptor.50,51 We did not observe any significant differences in the infiltration of neutrophiles and macrophages in zesto and kryo lesions, this may be due to immature endothelial sprouts in Zesto lesions, which retain extravasation barriers, hindering myeloid cell infiltration into the tumor microenvironment.