High genomic alterations in zesto lesions were inversely correlated with putative tumor suppressor genes (MTUS2, DLGAP3, RTN1, CRLF1, SLC12A5, and PDIA2) and positively correlated with APOBEC mutagenesis (APOBEC3C, APOBEC3G, APOBEC3B, and APOBEC3F) and hypoxia-related gene signatures (Figure 3B, bottom panel). This evidence concerns the gene PDIA2 and neoplasm.