NLRP3 and Alzheimer disease: Our results support previous findings in which BHB was found to impede NLRP3 inflammasome activation in response to multiple chemically distinct NLRP3 activators (Youm et al. 2015), in a 5XFAD mouse model of AD (Shippy et al. 2020), and recently in uric acid-treated murine muscle cell culture (Remund et al. 2024).