Thus, our goal is to scrutinize the effect of BHB in a high fat-fructose (HFFD)/LPS-induced sporadic AD model, focusing on its impact on CMA, Hsp70, NLRP3 inflammasome, and microglia activation to modulate Aβ and Ach/serotonin (5-HT) neurotransmitters. This evidence concerns the gene NLRP3 and Alzheimer disease.