In the same regard, the inhibitory role of Hsp70 in NLRP3 regulation has been reported in acute kidney injury models (Ullah et al. 2020), sepsis-induced cardiomyopathy (Song et al. 2022), and microglia pyroptosis-induced post-operative cognitive dysfunction (Lin et al. 2024). The gene discussed is NLRP3; the disease is acute kidney injury.