In our study, the used rat model increased Aβ in the hippocampus to promote M1 phenotype activation abetted by the increased NLRP3, which was validated by the increased activity of NOS2 and nitrated Aβ, as well as the upregulation of Iba-1 expression in the current hippocampal sections of AD rats, consistent with a previous finding (Heneka et al. 2013). This evidence concerns the gene NOS2 and Alzheimer disease.