Overall, the presented results highlight the valuable impact of BHB in mitigating AD pathology through the restoration of CMA activity, Hsp70 content, promotion of neuroprotective microglial activity, amelioration of neuroinflammation, and restoration of 5-HT and Ach contents to collectively inhibit Aβ and p-Tau. The gene discussed is MAPT; the disease is Alzheimer disease.