).61–64 In addition, recent network-based studies now suggest some initial evidence for hub-specific vulnerability to radiotoxicity.30,65 Future studies might consider the use of multimodal neuroimaging and incorporation of pre-treatment features of patients,43(eg, pre-existing white matter damage).66 Finally, some first findings on pre-treatment serum measurements suggest that lower levels of ApoJ, ApoE, or ApoA proteins and higher levels of amyloid beta (Aβ 1-42) could increase the risk of developing radiation-induced cognitive impairment.67 This evidence concerns the gene CLU and Cognitive impairment.