We established a 7-plex mIF panel to detect lymphoid aggregates and TLS using markers against T cells (CD3), B cells (CD20), mature dendritic cells (Lamp3), macrophages (CD163), as well as endothelial cells (vWF) and tumor cells (pan-cytokeratin or MelA) (Fig. 3a). This evidence concerns the gene LAMP3 and neoplasm.