JAK2 and acquired polycythemia vera: To further explore the link between JAK2 V617F mutations and epigenetic aberrations, we analyzed DNAm profiles in iPSC lines derived from three PV patients previously generated and independent of the above PMF samples, for each of them wild type (WT) JAK2, heterozygous (het), and homozygous (hom) JAK2 V617F mutations [21, 22].