Comparing healthy samples (n = 10) with MPN samples harboring specific driver mutations (n = 10 each), we identified 2,770 hyper- and 7,611 hypomethylated CpGs for JAK2, 2,361 and 9,426 for CALR, and 238 and 282, respectively, for MPL mutations (all adj p < 0.05; difference of mean DNAm > 20%; Fig. 2a-c). Here, CALR is linked to myeloproliferative neoplasm.