ISL2 and Alzheimer disease: By using JASPAR (a database of TF binding profiles) to predict TF binding, we found that the AD protective allele T of rs1532278 is within the TF binding motifs for ISL2 and DRGX (Fig. 1C), which are known to be expressed in postmitotic neurons (Fig. S2 C) [56, 57] and in our iGlut (Fig. S1B).