By using the ASoC approach, we systematically identified functional AD-associated variants in various human induced pluripotent stem cell (iPSC)-derived subtypes of neurons and glial cells [37] and found that among multiple AD risk variants at the CLU locus, only rs1532278 (T/C) was located in an open chromatin region (OCR) in human iPSC-derived neurons. The gene discussed is CLU; the disease is Alzheimer disease.