The immunohistochemistry results of IGFBP5 showed that the protein expression of IGFBP5 in the IDD and IDD + NC groups significantly increased compared with that in the Sham group, while the expression of IGFBP5 decreased after LV-shSTMN1 treatment, which further verified that STMN1 regulated IGFBP5 in cellular experiments. The gene discussed is IGFBP5; the disease is intervertebral disk degenerative disorder.