TGFB1 and neoplasm: The transforming growth factor beta (TGFβ) signalling pathway is constitutively activated in NSCLC tissues and cell lines by epigenetic down-regulation of the pseudo-receptor bone morphogenetic protein and membrane-bound activin inhibitor (BAMBI), resulting in tumour growth, epithelial-mesenchymal-transition (EMT) and phosphorylation of the receptor-regulated small mother against decapentaplegic homologue 3 (SMAD3) [8].