To examine whether SMAD2 linker phosphorylation during mitosis is a feature unique to malignant NSCLC cells or a generic phenomenon, we analysed T cells from healthy donors as a model for non-malignant cells, which can be induced to proliferate by CD3/CD28 double-bead activation and IL2 stimulation in vitro. Here, CD28 is linked to non-small cell lung carcinoma.