To explore the role of the EWSR1::FLI1-dependent increase in Tau expression for cancer-associated cellular phenotypes, we engineered the EwS cell line TC-32 with inducible inhibition of Tau expression (Fig. 3A) and the EwS cell line TC-71 with constitutive inhibition of Tau expression (Fig. 3B). The gene discussed is EWSR1; the disease is cancer.