RRM2 and neoplasm: Among these p53-related DEGs, SERPINE1, CD82 and THBS1 inhibit metastasis, invasion and angiogenesis of tumor cells [22], SHISA5, ZMAT3, FAS, TNFRSF10B, CASP8, CASP9, BAX, BBC3, and BCL2 promote cell apoptosis and increase sensitivity to drug [23], FAS and TNFRSF10B have also been reported to support CSC maintenance [24], CDKN1A, RRM2, GADD45B, and RRM2B mediate cell cycle arrest [25], and DRAM1, RRM2, and RRM2B are also required for the repair of DNA damage [26].