Due to that X-rays or cytotoxic drugs could increase p53 nuclear translocation [48, 49], the high-intensity chemotherapy and/or radiotherapy after tumor resection may override TSPYL5-driven cytoplasmic p53 retention, impairing the negative influence of TSPYL5 on p53 nuclear activity in patients with high-risk NB. The gene discussed is TSPYL5; the disease is neuroblastoma.