As a result, we observed clearly nuclear membrane aggregation of G3BP1 and cytoplasmic p53 sequestration in five cases of NB with abundant TSPYL5 expression, while such a phenotype of G3BP1 and p53 was absent in other three cases showing few TSPYL5 expression (Fig. 6F, Supplementary Fig. 11). The gene discussed is TSPYL5; the disease is neuroblastoma.