As a result, a total of 17 p53-related genes were confirmed to be remarkably differentially expressed in both NB cell lines (|log2fold change| > 2, Padj < 0.05) (Fig. 1C), totally suggesting the upregulation of p53 function in TSPYL5-knocked down NB cells (Fig. 1D). Here, TSPYL5 is linked to neuroblastoma.