Importantly, our recent investigation suggested that the high expression of TSPYL5 effects the cytoplasmic p53 sequestration and transcriptional inactivity in NB cells, providing an opportunity to shed light on the mechanism underlying the cytoplasmic sequestration of p53 by exploring the role of TSPYL5 in regulating p53 nucleocytoplasmic transport in NB tumors. Here, TSPYL5 is linked to neuroblastoma.