To explore if the IFN-γ-driven reduction of BMP signaling also results in altered Anxa1 expression, we performed ISH for Anxa1. Anxa1 expression was strongly upregulated in all epithelial cells along the crypt axis in WT but not in IFN-γR KO mice during acute colitis (Fig. 4a). This evidence concerns the gene IFNG and colitis.