Indeed, by sequencing the DNA coming from peripheral blood mononuclear cells (PBMCs) of 203 RR-MS patients with specific probes for the genes encoding for two main mitophagic receptors, NDP52 and Optineurin, the study revealed a significant association of NDP52 c.491G>A mutation (rs550510, p.G140E) with a decreased susceptibility to MS, suggesting that the NDP52 variant NDP52G140E may confer protection to MS. This evidence concerns the gene OPTN and myeloid sarcoma.