Immunoprecipitation in HA-CHMP5-expressing T-ALL cell nuclear lysates revealed p300 binding to CHMP5 (Supplementary Fig. 5e) and recombinant CHMP5 immunoprecipitated with p300 in cell-free assays (Fig. 4d), supporting a direct interaction between both proteins. The gene discussed is EP300; the disease is acute lymphoblastic leukemia.