Surprisingly, in addition to the cytosol, considerable amounts of CHMP5 proteins localized to the nucleus of human T-ALL lines (CUTLL1, MOLT-3, SUPT1) and patient-derived (PDX) T-ALL cells (Fig. 2a) as well as in normal human T cells (Supplementary Fig. 3a). Here, CHMP5 is linked to acute lymphoblastic leukemia.