In BRD4-dependent cancer cells, many pro-tumorigenic genes are notably enriched for BRD4 binding at enhancers and super-enhancers marked by histone hyperacetylation marks, including histone 3 lysine 27 acetylation (H3K27ac) that is chiefly characterized by the histone acetyl transferase (HAT) p30010,11. This evidence concerns the gene BRD4 and cancer.