Of note, regulation of NR3C1 and T-ALL response to GSI+Dex by CHMP5 was specific to NOTCH1-dependent T-ALL (CUTLL1) as NOTCH1-independent LOUCY T-ALL cells were unresponsive to GSI+Dex (Supplementary Fig. 6j–l). Here, CHMP5 is linked to acute lymphoblastic leukemia.