The analogous effect of CHMP5 depletion and p300 inhibition on MYC transcription combined with the lack of synergy between p300 inhibition (by CCS1477) and CHMP5 loss on T-ALL viability (Supplementary Fig. 5f) further corroborate that CHMP5 functions upstream of p300 (and BRD4). The gene discussed is BRD4; the disease is acute lymphoblastic leukemia.