BM chimera mice generated with ICN1-transduced WT donors as expected63 developed a fully penetrant lethal (median survival, ~5 weeks) T-ALL characterized by marked leukocytosis comprising T-ALL (i.e., CD45.2+NGFR+) cells, splenomegaly with disrupted white and red pulp zones, and substantial leukemic cell infiltration of tissues (Fig. 6a–d and Supplementary Fig. 7f, g). Here, NGFR is linked to acute lymphoblastic leukemia.