H3K27ac of the NOTCH-dependent MYC enhancer (NDME)18 was only mildly affected by loss of CHMP5 (Fig. 3n), likely reflecting that CHMP5 did not interact with ICN1 (Supplementary Fig. 3f) and may not regulate this enhancer in T-ALL cells. Here, MYC is linked to acute lymphoblastic leukemia.