NOTCH1 and acute lymphoblastic leukemia: CHMP5-depletion markedly increased AraC-induced cell death in both NOTCH1-dependent (CUTLL1 and SUPT1) and NOTCH1-independent (LOUCY) T-ALL cells, which reflected in a >10-fold reduction in the IC50 of AraC in CHMP5-KD T-ALL (Fig. 5e, f).