BRD4 and acute lymphoblastic leukemia: Validating their dependency on BRD4, treatment with JQ1 downregulated expression of genes (e.g., MYC, XBP1 and TCF7) with higher TRs in CHMP5-KD T-ALL cells was downregulated by JQ1 and this downregulation was comparable to the effect of CHMP5 depletion (Fig. 3i).