CHMP5 and acute lymphoblastic leukemia: Depletion of CHMP5 did not impact promoter-proximal (TSS) BRD4 binding, which remained largely unchanged in CHMP5-KD T-ALL cells (Supplementary Fig. 4a, b), so we assessed whether it instead controlled BRD4 binding and/or activity at distal enhancers and super-enhancers marked by hyperacetylated histone modifications, including H3K27ac44,45.