By reverse immunoprecipitation of endogenous BRD4, we confirmed the CHMP5-BRD4 interaction in nuclear lysates from T-ALL cell line and primary PDX human T-ALL (Fig. 2h, i) as well as in HEK293T cells co-transfected with plasmids encoding these proteins (Supplementary Fig. 3h). This evidence concerns the gene CHMP5 and acute lymphoblastic leukemia.