Immunophenotyping of BM, spleen and peripheral blood confirmed a marked depletion of T-ALL (i.e., CD45.2+NGFR+) cells in KO chimeras, unlike WT chimeras that harbored large numbers of CD45.2+NGFR+ T-ALL cells (Fig. 6d and Supplementary Fig. 7f). Here, NGFR is linked to acute lymphoblastic leukemia.