While in control T-ALL cells (CT), “hockey stick” plots of H3K27ac signals showed disproportionately higher H3K27ac density at super-enhancers of genes like MYC, TCF, ERG, and ETV6 as previously reported38, CHMP5 depletion markedly diminished these H3K27ac enhancers and super-enhancers (Fig. 3m), in line with diminished expression of these genes in CHMP5-KD T-ALL cells (Supplementary Fig. 4i). Here, HNF4A is linked to acute lymphoblastic leukemia.