Genome-wide TR correlation show increased TRs for critical T-ALL genes including MYC, XBP1, TCF7, PHB2, and CDK7 in CHMP5-KD T-ALL cells (Fig. 3g) and Pol II density at the 3’-ends of these genes was strikingly reduced (Fig. 3h). Here, XBP1 is linked to acute lymphoblastic leukemia.