Of note, like human T-ALL, primary CD4+CD8+ (double positive, DP) T-ALL cells in this murine T-ALL model expressed much higher amounts of CHMP5 than normal DP thymocytes (Supplementary Fig. 7e), suggesting that upregulation of CHMP5 in T-ALL cells is likely driven by oncogene activity. This evidence concerns the gene CD4 and acute lymphoblastic leukemia.