CHMP5 and acute lymphoblastic leukemia: Notably, increased sensitivity to GSI+Dex was associated with higher expression and nuclear translocation of the glucocorticoid receptor NR3C1, which upregulated NR3C1-target genes NR3C1 and BIM in CHMP5-KD T-ALL cells (Fig. 5i, j and Supplementary Fig. 6g).