In lung cancer, exosomes loaded with circRNA circ_0001715 and lncRNA HOXC‐AS2 enhance proliferation and metastasis by inducing the polarization of macrophages toward the M2 phenotype targeting the miR‐205‐5p/TREM2 axis85 and the STAT1/SOCS1 and STAT1/CIITA pathways,86 respectively, repressing the former and positively regulating the latter. Here, STAT1 is linked to lung cancer.