Exosomes loaded with ANGTPL1, a tumor suppressor that can be downregulated in different types of cancer like thyroid, colon, or breast,62, 63, 64 can inhibit angiogenesis in glioblastoma by reducing the expression of VEGFA and blocking the VEGFR2/AKT/eNOS pathway.65 Here, AKT1 is linked to neoplasm.