These findings propose a hierarchical ecosystem shaped by coordinated polarisation and inter‐compartment crosstalk, wherein three interdependent axes collectively contribute to tumour organisation: Differentiation‐invasion dichotomy (mutually exclusive Epi_Diff and Epi_pEMT states); Stromal reprogramming (imbalance between mCAF1 and cCAF populations); Immune lineage competition (inverse correlation of SPP1+ TAMs with NK/T). Here, SPP1 is linked to neoplasm.