Fluorescence intensities of DiR‐labelled EVs and CD38‐EVs (n = 3 per group), as well as PKH‐26‐labelled EVs and CD38‐EVs (n = 3 per group), were measured at various times using the FMP in vivo imaging system and ex vivo tumour tissue observation, comparing the tumour‐targeting efficiency of CD38‐EVsMNs with CD38‐EVsi.v. Here, PDXK is linked to neoplasm.