Results showed significantly higher uptake of CD38‐EVs by both RPMI8226 (Figure 2C) and U266 (Figure 2D) cells at 8 and 12 h, as confirmed by laser scanning confocal microscopy (LSCM), which showed the internalisation of CD38‐EVs into myeloma cells (Figure 2E). This evidence concerns the gene CD38 and plasma cell myeloma.