Since commercially available zonulin ELISA kits detect various structurally related ZFPs, whose levels decline with advancing liver disease and correlate more closely with hepatic synthetic capacity (albumin, haptoglobin) than IP in advanced cirrhosis [37, 38, 39], we focused on PV‐1 as a potentially independent prognostic biomarker for further analysis. The gene discussed is PLVAP; the disease is liver disorder.