Mouse double minute 2 (MDM2) E3 ligase stands out because it regulates the tumor suppressor p53 by inducing its degradation to maintain cellular homeostasis.[21] Dysregulation of p53 leads to a loss of its key function as a tumor suppressor, with p53 mutants gaining oncogenic properties.[22] The majority of malignant tumors have p53 mutated or inactivated, and rescuing wild type p53 with novel drugs is a good strategy to prevent tumor progression.[22]. The gene discussed is TP53; the disease is cancer.