Protective response against M. marinum in the zebrafish model of tuberculosis. The protective immune mechanisms included B‐cell maturation, antibody‐mediated opsonization of mycobacteria, Fc‐receptor (FcR)‐mediated phagocytosis, macrophage response, interference with the alpha‐Gal antagonistic effect of the TLR2/nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐kB)‐mediated immune response, and upregulation of pro‐inflammatory cytokines such as interleukin 1 beta (IL‐1β). This evidence concerns the gene IL1B and tuberculosis.