The infection with M. marinum activated Th1‐mediated protective mechanisms, reducing Th2 allergic AGS‐related symptoms in zebrafish inoculated with tick salivary components and fed on mammalian meat. However, metalloprotease and antigen p23 tick salivary proteins reduced M. marinum gut infection levels and the risk of tuberculosis through protective anti‐alpha‐Gal IgM antibodies and lowered expression of pro‐inflammatory cytokines and mediators (TNF‐α, IL‐1β, TLR2, and DNA‐PK). Here, CD40LG is linked to infection.