Future studies should conduct clinical trials and develop related test kits to confirm the role of LRRC4 in POI patients, meanwhile defining the clinical diagnostic thresholds of LRRC4 to predict ovarian reserve and menopausal age, which will contribute to the establishment of early warning for ovarian aging, as well as early diagnosis and timely treatment for diseases related to ovarian insufficiency. The gene discussed is LRRC4; the disease is ovarian dysfunction.