A previous report noted Subject‐R108C possessed homozygous MRPS14 variants (c.322C>T; p.R108C) that were associated with diffuse hypotonia, hypertrophic cardiomyopathy, cognitive disability, motor delays, along with elevated serum lactate and alanine levels (no neuroimaging results were reported) [4]. Here, MRPS14 is linked to hypertrophic cardiomyopathy.