IL10RA and osteoarthritis: To explore the function of IL‐10Rα in macrophages and chondrocytes, we generated bone marrow‐specific IL‐10Rα knockout (IL‐10RαLysm) mice (Figure S1A, Supporting Information) and conducted DMM on 3‐month‐old IL‐10RαLysm mice to elicit osteoarthritis and their littermate wild type (WT) controls (Figure2A).