In the HCC cohort, suPAR was significantly associated with ECOG performance status (rS = 0.438, p = 0.001) and the immune parameters C‐reactive protein (CRP) (rS = 0.321, p = 0.002) and relative lymphocyte count (rS = −0.359, p = 0.011). Here, CRP is linked to hepatocellular carcinoma.