Elevated neutrophil‐to‐lymphocyte ratio (NLR), neutrophil‐to‐monocyte ratio (NMR), platelet‐to‐lymphocyte ratio (PLR), neutrophil‐to‐platelet ratio (NPR), and C‐reactive protein (CRP) were found to be significant indicators of appendicitis, reflecting the underlying inflammatory response triggered by bacterial infection. Here, CRP is linked to bacterial infectious disease.