NR3C2 and Hyponatremia: A statistically significant association was also found between the class of diuretics administrated at home and the degree of hyponatremia, the association between the epithelial sodium channel inhibitor (ENaC-i) and hydrochlorothiazide being more frequent in severe cases (P = .038), and between loop diuretics and mineralocorticoid receptor antagonists in nonsevere ones (P = .031; Supplementary Table S3) (36).