The NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt (NCG) strain has been applied in B-cell acute lymphoblastic leukemia xenograft models to evaluate therapies such as induced natural killer (iNK) cells and CD19 CAR-engineered universal iNK cells [52]. This evidence concerns the gene CD19 and B-cell acute lymphoblastic leukemia.